If you are one of those (us) who constantly fucks with their software & interfaces (at least as much as you can) and you do this to the point that they are not just self-customized, but all screwed up and perhaps unusable anymore...well are you? If so ADSK has a tool for you!!! Click on Resetting the Revit Architecture 2010 user interface for their Knowledge Base Search document explaining it all... including the all necessary .vbs file and everything!!!
Now just leave the interface alone and get to work!!!
Have a great weekend!!!